17, 18 These class of compounds are used in the design of therapeutics targeting cancer 19, 20 e.g. histone deacetylases HDACs inhibitors like vorinostat, belinostat, panobinostat and trichostatin A, 21 cardiovascular diseases 22 e.g. hydroxyurea, 24 Alzheimer s, 25 malaria 26, 27 e.g. Keywords: Keyword Histone deacetylase inhibitors, Matrix metalloproteinase inhibitors, HIV, Hydroxamaates, Ribonucleoside diphosphate reductase Cite this paper: David I. The reasonable way of producing hydroxamic acid derivative is the reaction of hydroxylamine with acid chlorides or esters.
29 The wide biological application of hydroxamates necessitates the review of its synthesis and biological applications. General Synthesis of Weinreb Amides Hydroxamic acids are prepared usually from esters or acid chlorides or carboxylic acids.2.1.
The TBS group was later recovered with tetra- normal-butylammonium fluoride TBAF in THF to give alcohol 28 in 91 yields.
The second portion of the synthesis is presented in schemes 10.
The reaction of carboxylic acid 1eq and 2-chloro-4,6-dimethoxy-1,3,5-triazine 1.2 eq in the presence of N-methyl morpholine 3 eq., THF at room temperature for 1-3 h gave the 4,6-dimethoxy-1,3,5-triazine intermediate 20, compound 20 upon treatment with substituted hydroxylamine 1 eq at room temperature for 8 h gave the target product 21.
There are many more general synthetic routes that have been reported and cannot be described for lack of space but are mentioned in this review.